Nanoscale Reports

Evaluation of Antibacterial and In vivo Wound healing activity of Carbon Dot Nanoparticles

2019-07-14T09:27:08+00:00

Treating post-surgical wound is one of the major challenges in the field of medical Science due to the several disadvantages posed by the antibiotics. The antimicrobial and Wound healing activity of metal based nanoparticles were well known, but the effects of carbon dot nanoparticles (C-Dots) are less explored. In the present study a wet chemical method for the synthesis of C-Dots from sucrose, glucose and fructose was developed and they were characterized by UV-Visible, Fluorescent spectroscopic techniques and the pharmaceutical applications such as antibacterial and the wound healing activities were evaluated. The study revealed that the C-Dots synthesized from Sucrose (SCD) and Glucose (GCD) showed potent antibacterial activity against both positive and negative bacterial strains at 12.5µl/ml (0.1 ± 0.003) and Fructose (FCD) at 50 µl/ml (0.1 ± 0.01) compared to the vehicle Control (0.61 ± 0.06). The wound healing of SCD (367.8 ± 15.2) was observed better than the Control (280.8 ± 10.72) and FCD (326.8 ± 9.41). GCD (166.8 ± 10.83) skin tissues indicated best healing as compared to FCD (135.8 ± 8.29), SCD (157.3 ± 16.97) and Control (135.8 ± 8.29). The results suggest that C-Dots applied topically possess wound healing activity and have potential applications as a bacteriostatic agent.

Nanoparticle synthesis approaches at a glance

2019-07-14T09:27:08+00:00

Nanotechnology has opened a new era for scientists and engineers to build nanomaterials with diverse applications. Nowadays, nanotechnology plays a vital role
in each and every sector due to its extraordinary physical and chemical properties. It deals with development and synthesis of variety of nanoparticles (NPs), which ranging from 1 to 100 nm. The major approaches used for the synthesis of NPs are top to bottom and bottom to up which mainly included physical, chemical and biological methodologies. This mini review highlights synthesis of NPs through various approaches specifically targeted biological route.

Study of a-C:H thin films deposited by Plasma Immersion Ion Implantation for mechanical and tribological applications

2019-07-14T12:47:06+00:00

The tribological and mechanical properties of DLC films deposited on the surface of 16MnCr5 steel alloy were investigated. The major concerning of using DLC layers on engine parts are: (i) to reduce friction; (ii) to increase fuel efficiency and to reduce CO₂ emission; (iii) to increase hardness of alloy steel. After polished and ultrasonicated, 16MnCr5 substrates were submitted to PIIID procedures in radiofrequency plasmas (13.56 MHz) generated from atmospheres of methane and argon. Excitation power and total gas pressure were kept constant. It was investigated the effect of methane proportion on the microstructure and mechanical properties of the films using the follow techniques: Raman Spectroscopy (for Hydrogen content and microstructure analysis), Ultra Micro-Tribometer (for friction coefficient) and Nanoindentation (hardness evaluation). Raman analysis confirmed DLC character of the films produced, and the proportion of 80% methane and 20% argon resulted to the best performance of mechanical properties of the films owing to the increase of hardness in until ten times, and reducing the friction coefficient to about 0.2. In addition, thickness for these films varied from 165 nm to 206 nm.