Serum Fasting Lipid Profile of Children with β- Thalassemia Major in Peshawar, Pakistan
Beta thalassemia (β-thalassemia) is one of the most common inherited disorder caused number of mutations in the beta globin gene. Most important problem encountered in thalassemic patients are diabetes. Vascular dysfunction with increased arterial stiffness and endothelial dysfunction has been found in patients with β-thalassemia. Endothelial dysfunction occurs in thalassemic children because of per oxidative tissue injury because of continuous blood transfusions. The aim of the study was to examine different lipid component levels in serum fasting of children having β-thalassemia major. A cross sectional study was carried out on 40 β-thalassemia patients. After examining the serum of patients show high value of high-density lipoprotein have significant decrease in their bilirubin content. While high value of high-density lipoprotein results in decrease of low-density lipoprotein content in serum. The age group 10-15 years was described as the highest risk group of β-thalassemia between the investigated populations. Our study revealed that deranged lipid profile is not uncommon in β-thalassemia patients irrespective of age and gender. Considerable deficiency of HDL and significantly high TC: HDL could be predictive for future coronary events. The study propose that lipid profile should be evaluated in these patients as low HDL and raised TC: HDL are important tools for coronary risk assessment. The exact mechanisms and clinical consequences of dyslipidaemia in β-thalassemia should be further investigated in larger prospective studies to represent the Pakistan population.
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